The Global Kidney Crisis

Size of Problem:

•Currently over 100,000 Patients on Waiting List in US

•More than 350,000 on dialysis in US

•Over 1.2 million people that are kidney transplant candidates globally 

Human Suffering:

•Takes 3.6 years to get a transplant. 

•After 10 years, many transplanted Kidneys need to be replaced

•Approximately 8400 waiting transplant patients per year die or get so sick they can’t receive transplants

Cost to Medical System:

•In 2016, treating Medicare beneficiaries with CKD cost over $79 billion, and treating people with ESRD cost an additional $35 billion. (1)

•More than 200,000 veterans have Chronic Kidney Disease (2)


(2)Am J Kidney Dis. 2014;63(3):521-529


About Mesogen



There is a huge unmet need in kidney transplantation. Mesogen’s mission is to create custom human kidneys from the patient’s own stem cells in less than a year. The patient will not require long term anti-rejection drugs.

  • Our market in the United States includes patients awaiting for kidney transplant ($35 billion opportunity) as well as patients added to the kidney transplant waiting list every year ($5 billion per year opportunity). 
  • The worldwide opportunity is more than $120 billion. 
  • Pharmaceutical companies looking for human kidney models to test drugs and therapies could be an upside market opportunity.


Mesogen’s mission will be a provider of kidneys for transplant. 

  • The kidneys for transplant will initially be grown in the Texas laboratory facility and the animals that have served as the kidney bioreactor will be shipped to the respective transplant centers for kidney harvest and transplant into the patient.
  • The company headquarters will be located in the Woodlands, Texas, in the United States.


Michael C. Riddle Jr., MD

Founder, CEO

•Michael C. Riddle Jr., MD graduated from the University of Texas Medical Branch. 

•He has over 15 years of clinical and molecular laboratory experience having worked at the University of Texas, MD Anderson's Molecular Diagnostic Laboratory, Memorial Hermann Hospital and the US Navy.

•Research projects include lung, kidney, heart and heart valve regenerative medicine research. 

•He developed a human lung bioreactor which was sold to Harvard Apparatus.

•Dr. Riddle also invented a pediatric heart valve bioreactor that was sold to Mayo Clinic. 

•He specializes in designing and building custom bioreactors for regenerative medicine applications and other medical technology devices.

•His publications include: 

•Giving New Life to Old Lungs: Methods to Produce and Assess Whole Human Pediatric Bioengineered Lungs in the Journal of Tissue Engineering and Regenerative Medicine 

•Production and Assessment of Decellularized Pig and Human Lung Scaffolds in Tissue Engineering Part A 

•Dr. Riddle has several patents in the life sciences technology arena.


  Joaquin Cortiella, MD 

• Director of the University of Texas Medical Branch Regenerative and Nano-medicine Laboratory

• Colonel serving with the 399th Combat Support Hospital in Massachusetts 

• M.D. from Boston University Medical School, B.A. from Harvard. 

• Extensive expertise in tissue engineering including production of skin, lung, cartilage 

 •Experience using adult and embryonic stem cells as well as tissue engineering techniques to produce human ex-vivo organoids/tissue constructs

•Experience using adult and embryonic stem cells as well as tissue engineering techniques to produce human ex-vivo organoids/tissue constructs

Stephen Fadem, MD

•Dr. Fademis a practicing Houston nephrologist. He began practice in 1978 after completing a renal fellowship at The University of Texas Health Science Center in San Antonio. 

•He is a graduate of the University of Oklahoma College of Medicine, and The University of Texas and MD Anderson Hospital in Houston. 

•He is a Clinical Professor of Medicine at Baylor College of medicine. 

•He is also a member of the American Society of Nephrology, International Society of Nephrology, Renal Physicians Association, and The National Kidney Foundation.

•He was a founding member, and first president of the Gulf Coast Kidney Society. He is the Medical Advisory Board Chairman of the National Kidney Foundation Serving Texas

John Phelps III, MD

•Dr. John Phelps is an obstetrician-gynecologist in League City, Texas and is affiliated with multiple hospitals in the area, including Houston Methodist Clear Lake Hospitaland University of Texas Medical Branch

•He received his medical degree from Georgetown University School of Medicine and has been in practice for more than 20 years. 

•Dr. Phelps’ Specialty / Subspecialties: Obstetrics & Gynecology / General Obstetrics & Gynecology, Minimally Invasive / Endoscopic Surgery, Reproductive Endocrinology & Infertility


Carl McCutcheon

•Carl is the Chairman of the Mesogen Advisory Board. He is a serial entrepreneur, with experience in capital formation for early stage ventures and has built and led several early stage teams that have closed of $9 billion of transactions in energy and technology. 

•He has served on the Advisory Board of the Riddle Institute of Regenerative Technology for four years and is the past Vice Chairman of the Houston Technology Center Advisory Board

•Carl McCutcheon graduated from the Harvard Business School and Northwestern University’s Kellogg School of Management.

Don Benson

•Don Benson has an extensive senior management and Board of Directors experience including CHR Solutions, Inc. where he has served as Chairman.

•His background in life sciences management includes roles as President and CEO of Methodist Office Building Company, Senior VP of Methodist Healthcare System, and Senior VP of National Nephrology Associates

•He has an extensive background in insurance, having served as Senior VP of CIGNA, VP of Aetna, and Board Member of Employer Direct Healthcare, Inc. 

•Mr. Benson has been involved in approximately 100 major acquisitions, mergers and divestitures exceeding $20 billion in combined value.

Paul Frison

•Paul has been President and/or CEO of three public companies: LifeMark(1975 – 1984 NYSE) ComputerCraft(1984 – 1986 NASDAQ) and LifeCell(1986 – 1999 NASDAQ), each technology based. 

•He has been involved in four other start-ups by serving on their boards of directors. His experience includes numerous mergers and acquisitions. He has raised multiple rounds of venture capital, two IPOs, and more than a dozen follow-on rounds of public financing. 

•In 1999, Paul became the initial employee and was elected President and CEO of the Houston Technology Center (HTC), a business incubator and accelerator. He served as CEO/Chairman until February 2007, when he became Executive Vice Chairman. He received the 2004 Ernst & Young Entrepreneur of the Year Award for Entrepreneurship Supporter. 

Andrew Nat Jr.

•Andrew is an experienced life sciences and energy executive and Board Member that has closed over $2.6 billion of transactions. 

•He currently serves as the Managing Partner of ThirdwavePartners and is focused on corporate strategy, business development, mergers and acquisitions, and private equity.

•He has been a Principal in Neos Resource Partners, Executive Vice President of Texas Bioalliance, Executive Director of the Commercial Review Council for the Cancer Prevention and Research Institute, and Executive Director, Member of the Board of Directors for the Texas Life Science Center.

•Andrew has an MBA from Yale and a BA from Columbia University

Larry Wyche

•Larry is currently Founder and Chief Executive Officer of Wyche Consulting which provides strategic support for his clients’ international business development strategy and leadership.

•Formerly Larry served for 35+ years in the US Army, retiring as a Lieutenant General responsible for 120,000 military personnel in 152 countries, with an annual budget of $58 billion.

•He is a member of the National Association of Corporate Directors and serves as a Board Member for the Houston Food Bank

•He graduated from the National Defense University, the Florida Institute of Technology, Texas A&M and the National Association for Corporate Directors Leadership Program.


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8777 West Rayford Rd. The Woodlands, Texas 77389 US

(832) 247-3218